The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate–carbohydrate interactions, CCIs) of Tn (Tn–Tn) and STn (STn–STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.

中文翻译：

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Tn和STn是具有碳水化合物与碳水化合物相互作用的碳水化合物肿瘤抗原家族的成员

癌症中的粘蛋白型O糖异常表达截短的聚糖Tn（GalNAcα1-Ser/ Thr）和STn（Neu5Acα2,6GalNAcα1-Ser/ Thr）。但是，人们对Tn和STn在癌症和其他疾病中的作用还不甚了解。我们最近发现的Tn（Tn–Tn）和STn（STn–STn）的自结合特性（碳水化合物-碳水化合物相互作用，CCI）为它们在细胞转化中的可能作用提供了一个模型。我们还审查了证据，即Tn和STn是拥有CCI的更大的聚糖肿瘤抗原家族的成员，而CCI可能参与了肿瘤的发生。