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One-Pot Synthesis of a Bismuth Selenide Hexagon Nanodish Complex for Multimodal Imaging-Guided Combined Antitumor Phototherapy
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-04-02 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00106 Yilin Song 1 , Jinping Wang 1 , Li Liu 1 , Qi Sun 1 , Qing You 1 , Yu Cheng 1 , Yidan Wang 1 , Siyu Wang 1 , Fengping Tan 1 , Nan Li 1
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-04-02 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00106 Yilin Song 1 , Jinping Wang 1 , Li Liu 1 , Qi Sun 1 , Qing You 1 , Yu Cheng 1 , Yidan Wang 1 , Siyu Wang 1 , Fengping Tan 1 , Nan Li 1
Affiliation
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For integrating therapy and diagnosis into a single nanoparticle for higher antitumor efficiency and lower toxicity, our group designed a smart theranostic nanoplatform based on a hyaluronic acid-doped polypyrrole-coated bismuth selenide loading with a zinc phthalocyanine nanodish complex (Bi2Se3@HA-doped PPy/ZnPc) for multimodal imaging-guided combined phototherapy. Moreover, we expect that the HA-doped PPy smart shell for the surface functionalization will also be applied to a variety of 2D nanomaterials sharing a similar structure with Bi2Se3 to broaden their applications in biomedicine. The Bi2Se3 hexagon nanodish was synthesized via a simple and safe solution-based method compared to the commonly adopted ones. A one-pot synthesis of the naoncomplex was carried out by adding HA during the polypyrrole coating on the Bi2Se3 process, and then it was further loaded with ZnPc. Besides the good ability for infrared thermal, photoacoustic, fluorescence, and X-ray computed tomography imaging, the nanodish complex has its own high photoheat conversion efficiency for photothermal therapy, and it has remarkable optical absorption of the coefficient for photodynamic therapy. With the EPR effect of nanoparticles and the CD44-targeted effect of HA, the tumor-growth inhibition ratio of Bi2Se3@HA-doped PPy/ZnPc for PTT/PDT was as high as 96.4%, compared with that of the PTT (68.0%) or PDT (24.3%) alone, showing an excellent combined therapeutic effect. Moreover, no obvious toxicity in vivo was caused by the nanoparticles. Thus, such a Bi2Se3@HA-doped PPy/ZnPc nanodish complex has promise for real-time monitoring and precise, high-efficiency antitumor treatment.
中文翻译：
一锅合成硒化铋六角纳米盘复合物用于多模态成像引导联合抗肿瘤光疗
为了将治疗和诊断整合到单个纳米颗粒中，以提高抗肿瘤效率和降低毒性，我们小组基于玻尿酸掺杂的聚吡咯涂层硒化铋与锌酞菁纳米盘配合物（Bi 2 Se 3 @HA）设计了一种智能的治疗疗法纳米平台。掺杂的PPy / ZnPc）用于多峰成像引导的联合光疗。此外，我们希望用于表面功能化的HA掺杂PPy智能外壳也将应用于与Bi 2 Se 3具有相似结构的2D纳米材料，以扩大其在生物医学中的应用。Bi 2 Se 3与常用的相比，六边形纳米盘是通过一种简单且安全的基于溶液的方法合成的。通过在Bi 2 Se 3工艺上的聚吡咯涂层过程中添加HA，可以一锅法合成钠配合物，然后进一步加载ZnPc。除了具有良好的红外热，光声，荧光和X射线计算机断层摄影成像能力外，该纳米盘复合物还具有自身对光热疗法的高光热转换效率，并且对光动力疗法具有显着的光吸收系数。具有纳米粒子的EPR作用和HA的CD44靶向作用，Bi 2 Se 3的肿瘤生长抑制率与单独的PTT（68.0％）或PDT（24.3％）相比，@ HA掺杂的PTy / PDT的PPy / ZnPc高达96.4％。而且，纳米颗粒没有在体内引起明显的毒性。因此，这种Bi 2 Se 3 @HA掺杂的PPy / ZnPc纳米盘复合物有望用于实时监测和精确，高效的抗肿瘤治疗。
更新日期：2018-04-02
中文翻译：
一锅合成硒化铋六角纳米盘复合物用于多模态成像引导联合抗肿瘤光疗
为了将治疗和诊断整合到单个纳米颗粒中，以提高抗肿瘤效率和降低毒性，我们小组基于玻尿酸掺杂的聚吡咯涂层硒化铋与锌酞菁纳米盘配合物（Bi 2 Se 3 @HA）设计了一种智能的治疗疗法纳米平台。掺杂的PPy / ZnPc）用于多峰成像引导的联合光疗。此外，我们希望用于表面功能化的HA掺杂PPy智能外壳也将应用于与Bi 2 Se 3具有相似结构的2D纳米材料，以扩大其在生物医学中的应用。Bi 2 Se 3与常用的相比，六边形纳米盘是通过一种简单且安全的基于溶液的方法合成的。通过在Bi 2 Se 3工艺上的聚吡咯涂层过程中添加HA，可以一锅法合成钠配合物，然后进一步加载ZnPc。除了具有良好的红外热，光声，荧光和X射线计算机断层摄影成像能力外，该纳米盘复合物还具有自身对光热疗法的高光热转换效率，并且对光动力疗法具有显着的光吸收系数。具有纳米粒子的EPR作用和HA的CD44靶向作用，Bi 2 Se 3的肿瘤生长抑制率与单独的PTT（68.0％）或PDT（24.3％）相比，@ HA掺杂的PTy / PDT的PPy / ZnPc高达96.4％。而且，纳米颗粒没有在体内引起明显的毒性。因此，这种Bi 2 Se 3 @HA掺杂的PPy / ZnPc纳米盘复合物有望用于实时监测和精确，高效的抗肿瘤治疗。
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