Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model,Food & Function

当前位置： X-MOL 学术 › Food Funct. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model
Food & Function ( IF 5.1 ) Pub Date : 2018-04-02 00:00:00 , DOI: 10.1039/c7fo01858d
Junsheng Liu _{1,

2,

3,

4,

5} , Zhennan Gu _{1,

2,

3,

4,

5} , Wenwei Lu _{1,

2,

3,

4,

5} , Diangeng Hu _{1,

2,

3,

4,

5} , Xi Zhao _{4,

6,

7,

8} , Hongxuan Huang _{1,

2,

3,

4,

5} , Hao Zhang _{1,

2,

3,

4,

5} , Jianxin Zhao _{1,

2,

3,

4,

5} , Wei Chen _{1,

2,

3,

4,

5}

Affiliation

Probiotics are now prevalent world-wide, as functional food supplements with many benefits for humans and animals, such as protective effects against pathogenic infection. We showed that oral supplementation of Lactobacillus pentosus AT6 (AT6) decreased the mortality rate of mice with Salmonella infection. A series of experiments showed that the protective effects of AT6 on mice involved multiple mechanisms, including (1) the inhibition of Salmonella Typhimurium growth by AT6 or its cell-free culture supernatants (CFCSs); (2) the reduction of the bacterial loads of Salmonella Typhimurium in intestinal contents and internal organs, such as the liver and spleen; (3) the inhibition of adhesion and invasion of Salmonella Typhimurium into intestinal epithelial cells; and (4) the regulation of host immunities by modifying the production of a chain of cytokines. In conclusion, AT6 inhibited Salmonella infection via multiple mechanisms and therefore has great potential for the development of functional foods with anti-Salmonella activities.

中文翻译：

戊糖乳杆菌AT6抑制小鼠 沙门氏菌致死作用的多种机制

益生菌作为一种功能性食品补充剂，在人类和动物身上具有许多益处，例如对病原体感染的保护作用，现已在全球范围内普及。我们表明，口服补充戊糖乳杆菌AT6（AT6）可以降低沙门氏菌感染小鼠的死亡率。一系列实验表明，AT6对小鼠的保护作用涉及多种机制，包括（1）AT6或其无细胞培养上清液（CFCSs）抑制鼠伤寒沙门氏菌的生长；（2）减少鼠伤寒沙门氏菌在肠内容物和肝脏和脾脏等内部器官中的细菌负荷；（3）抑制沙门氏菌的黏附和侵袭鼠伤寒进入肠上皮细胞；（4）通过修饰细胞因子链的产生来调节宿主的免疫力。总之，AT6通过多种机制抑制沙门氏菌感染，因此具有开发具有抗沙门氏菌活性的功能性食品的巨大潜力。

更新日期：2018-04-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11