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Next generation sequencing assisted in establishing the diagnosis and treatment for a Chinese patient with breast and lung multiple primary malignancies
Journal of Thoracic Oncology ( IF 21.0 ) Pub Date : 2018-07-01 , DOI: 10.1016/j.jtho.2018.03.019 Chunqing Song , Zhengxing Gao , Jiabao Zong , Junping Shi , Ming Yao , Guilong Lu , Xiaoliang Liu , Kai Wang , Lei Han
Journal of Thoracic Oncology ( IF 21.0 ) Pub Date : 2018-07-01 , DOI: 10.1016/j.jtho.2018.03.019 Chunqing Song , Zhengxing Gao , Jiabao Zong , Junping Shi , Ming Yao , Guilong Lu , Xiaoliang Liu , Kai Wang , Lei Han
INTRODUCTION
A case of primary lung cancer was reported, which was misdiagnosed as breast cancer metastasis to the lung based on pathology in combination with a history of breast cancer. METHODS
The common driver gene mutation was detected in different lesions by next generation sequencing (NGS), and it was shown that the genomic profiling of lung lesion and breast lesion were inconsistent. RESULTS
The typical driver mutation of EGFR L858R in lung cancer was found in lung lesion, and the patient received the first-generation EGFR-TKI, icotinib, as treatment and achieved a partial response. CONCLUSIONS
With NGS detection in this case, the specific driver gene in the tumor site was identified, which facilitated the diagnosis of a double primary cancer, and resulted in a change in treatment.
更新日期：2018-07-01
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