DARK Classics in Chemical Neuroscience: Methamphetamine,ACS Chemical Neuroscience

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DARK Classics in Chemical Neuroscience: Methamphetamine
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-03-30 00:00:00 , DOI: 10.1021/acschemneuro.8b00123
Thomas J. Abbruscato ₁ , Paul C. Trippier ₁

Affiliation

Methamphetamine has the second highest prevalence of drug abuse after cannabis, with estimates of 35 million users worldwide. The (S)-(+)-enantiomer is the illicit drug, active neurostimulant, and eutomer, while the (R)-(−)-enantiomer is contained in over the counter decongestants. While designated a schedule II drug in 1970, (S)-(+)-methamphetamine is available by prescription for the treatment of attention-deficit disorder and obesity. The illicit use of (S)-(+)-methamphetamine results in the sudden “rush” of stimulation to the motivation, movement, pleasure, and reward centers in the brain, caused by rapid release of dopamine. In this review, we will provide an overview of the synthesis, pharmacology, adverse effects, and drug metabolism of this widely abused psychostimulant that distinguish it as a DARK classic in Chemical Neuroscience.

中文翻译：

化学神经科学领域的经典著作：甲基苯丙胺

甲基苯丙胺是仅次于大麻的第二大药物滥用流行率，估计全世界有3500万使用者。（S）-（+）-对映异构体是非法药物，活性神经刺激剂和eutomer，而（R）-（-）-对映异构体包含在非处方充血剂中。（S）-（+）-甲基苯丙胺在1970年被指定为附表II药物，可通过处方用于治疗注意力缺陷障碍和肥胖症。（S的非法使用）-（+）-甲基苯丙胺导致多巴胺的快速释放引起对大脑的动机，运动，愉悦和奖励中心的突然“冲动”。在这篇综述中，我们将概述这种广泛滥用的精神兴奋剂的合成，药理学，不良反应和药物代谢，将其区别为化学神经科学中的暗黑经典。

更新日期：2018-03-30

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