Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3,Journal of Natural Products

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Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-03-30 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00164
Zhen-Zhen Shi _{1,

2} , Feng-Ping Miao ₁ , Sheng-Tao Fang ₁ , Xiu-Li Yin ₁ , Nai-Yun Ji ₁

Affiliation

Three novel polyketide-like metabolites, trichorenins A–C (1–3), with a unique tetracyclic carbon skeleton were obtained from the culture of Trichoderma virens Y13-3, an epiphyte of the marine red alga Gracilaria vermiculophylla. Their structures and relative configurations were established by analysis of 1D/2D NMR and MS data, and their absolute configurations were unequivocally assigned by X-ray diffraction and ECD spectra aided by quantum chemical calculations. Compounds 1–3 exhibited potent inhibition against two marine phytoplankton species, Chattonella marina and Karlodinium veneficum.

中文翻译：

从海洋藻类表生真菌中提取的木霉菌素A–C，藻类四环代谢产物绿霉菌Y13-3

三种新型聚酮化合物类代谢物，trichorenins A-C（1 - 3）中，用得到的唯一四环碳骨架从培养绿木霉Y13-3，海洋的真菌红藻龙须vermiculophylla。通过对1D / 2D NMR和MS数据的分析，确定了它们的结构和相对构型，并通过量子化学计算辅助的X射线衍射和ECD谱明确地确定了它们的绝对构型。化合物1 – 3对两种海洋浮游植物种类，滨海沙通氏菌和veneficum浮游植物具有有效的抑制作用。

更新日期：2018-03-30

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