Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the roots of Kadsura longipedunculata. Compounds 6–10 are new spirobenzofuranoid–dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.

中文翻译：

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来自 Kadsura longipedunculata 的保肝二苯并环辛二烯和四氢苯并环辛苯并呋喃酮木脂素

五种新的二苯并环辛二烯木脂素、longipedlignans A–E ( 1 – 5 )、五种新的四氢苯并环辛二苯并呋喃酮 ( 6 – 10 ) 和 18 种已知的类似物 ( 11 – 28 ) 从Kadsura longipedunculata的根中分离出来。化合物6-10是新型螺环苯并呋喃-二苯并环辛二烯型木酚素类化合物。它们的结构和绝对配置是使用 MS、NMR 和电子圆二色性数据的组合建立的。Spirobenzenofuranoids 6和15对N -acetyl- p显示出适度的保肝活性-氨基苯酚在 HepG2 细胞中诱导的毒性，细胞存活率在 10 μM 时分别为 52.2% 和 50.2%。