Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata,Journal of Natural Products

当前位置： X-MOL 学术 › J. Nat. Prod. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-03-29 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00934
Jiabao Liu ₁ , Pankaj Pandey , Xiaojuan Wang ₂ , Xinzhu Qi ₁ , Jiabao Chen ₁ , Hua Sun ₁ , Peicheng Zhang ₁ , Yuanqing Ding , Daneel Ferreira , Robert J Doerksen , Mark T Hamann ₂ , Shuai Li ₁

Affiliation

Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the roots of Kadsura longipedunculata. Compounds 6–10 are new spirobenzofuranoid–dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.

中文翻译：

南五味子的保肝二苯并环辛二烯和四氢苯并环辛苯并呋喃酮木脂素

从长柄南风藤根中分离出五种新的二苯并环辛二烯木脂素、长柄木脂素 A-E ( 1-5 )、五种新的四氢苯并环八苯并呋喃酮 ( 6-10 ) 和 18 种已知类似物 ( 11-28 )。化合物6-10是新的螺苯并呋喃类-二苯并环辛二烯型木脂素。结合 MS、NMR 和电子圆二色性数据确定了它们的结构和绝对构型。螺苯并呋喃类化合物6和15对 HepG2 细胞中N-乙酰基-对氨基苯酚诱导的毒性表现出中等的保肝活性，10 μM 时的细胞存活率分别为 52.2% 和 50.2%。

更新日期：2018-03-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11