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Effect of solar ultraviolet radiation exposure on serum 25(OH)D concentration: a pilot randomised controlled trial†
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-03-29 00:00:00 , DOI: 10.1039/c7pp00378a Shanchita R. Khan 1, 2, 3, 4, 5 , David C. Whiteman 4, 5, 6, 7 , Michael G. Kimlin 4, 8, 9, 10 , Monika Janda 1, 2, 3, 4, 11 , Michael W. Clarke 12, 13, 14, 15, 16 , Robyn M. Lucas 4, 17, 18, 19, 20 , Rachel E. Neale 4, 5, 6, 7
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-03-29 00:00:00 , DOI: 10.1039/c7pp00378a Shanchita R. Khan 1, 2, 3, 4, 5 , David C. Whiteman 4, 5, 6, 7 , Michael G. Kimlin 4, 8, 9, 10 , Monika Janda 1, 2, 3, 4, 11 , Michael W. Clarke 12, 13, 14, 15, 16 , Robyn M. Lucas 4, 17, 18, 19, 20 , Rachel E. Neale 4, 5, 6, 7
Affiliation
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Sunlight generates vitamin D, but there are scant human data from randomised trials on which to base health policy advice about how much sun exposure is necessary to change 25(OH)D concentrations. The purpose of the study was to evaluate the feasibility of using solar ultraviolet (UV) radiation exposure to generate a change in 25(OH)D concentration in a randomised controlled trial (RCT). The intervention tested in this RCT was supervised exposure to one standard erythemal dose (SED; 100 J m−2) of solar UV radiation three days per week for three weeks with approximately 35% of the body surface area not covered by clothing. Thirty-six fair-skinned (skin type II and III) indoor workers from Brisbane, Australia were randomised into either the intervention group (n = 16) or the control group (n = 20); the latter did not receive any supervised sun exposure. We asked both groups to use sunscreen and to minimise time outdoors during the study period. We collected blood samples at baseline, once per week during the three week intervention period, and four weeks after the intervention finished. The cumulative UV radiation exposure over the intervention period measured using polysulphone badges was higher in the intervention group than in the control group (median 8 vs. 4 SEDs, p = 0.14). After three weeks, the mean serum 25(OH)D concentration increased from 60 to 65 nmol l−1 in the intervention group and from 55 to 57 nmol l−1 in the control group. After adjustment for baseline 25(OH)D, the mean change per week during the intervention phase was non-significantly higher in the intervention than in the control group (0.7 vs. 0.3; p = 0.35). This difference was not sustained during the follow-up period. Large field trials are needed to inform policy about how much natural sun exposure is required to raise 25(OH)D concentrations. This pilot identified key issues that need to be considered in the design of such a trial.
中文翻译：
太阳紫外线辐射对血清25（OH）D浓度的影响：一项中试随机对照试验†
阳光会产生维生素D，但是从随机试验中获得的人体数据很少，因此无法根据健康政策建议来改变25（OH）D的浓度需要多少阳光。该研究的目的是评估在随机对照试验（RCT）中使用太阳紫外线（UV）辐射产生25（OH）D浓度变化的可行性。在该RCT中测试的干预措施是有监督地每周三天，每天三天暴露于一种标准的红斑剂量（SED; 100 J m -2）的太阳紫外线辐射下，三周内没有衣服覆盖身体表面积的35％。来自澳大利亚布里斯班的36名白皙（II型和III型皮肤）室内工人被随机分为干预组（n= 16）或对照组（n = 20）；后者没有接受任何有监督的日光照射。我们要求两组在研究期间都使用防晒霜，并尽量减少在户外的时间。我们在基线时，在为期三周的干预期间每周一次以及在干预结束后的四个星期收集血液样本。在干预期间，使用聚砜徽章测量的累积紫外线辐射暴露在干预组中高于对照组（中位数为8 vs. 4 SED，p = 0.14）。三周后，干预组的平均血清25（OH）D浓度从60 nmol l -1增加到65 nmol l -1，从55 nmol L -1增加到57 nmol l -1在对照组中。调整基线25（OH）D后，干预阶段每周的平均变化与对照组相比无显着差异（0.7 vs. 0.3; p = 0.35）。在随访期间这种差异没有得到维持。需要进行大范围的现场试验，以告知政策要增加25（OH）D的浓度需要多少自然阳光照射。该飞行员确定了在设计此类试验时需要考虑的关键问题。
更新日期：2018-03-29
中文翻译：
太阳紫外线辐射对血清25（OH）D浓度的影响：一项中试随机对照试验†
阳光会产生维生素D，但是从随机试验中获得的人体数据很少，因此无法根据健康政策建议来改变25（OH）D的浓度需要多少阳光。该研究的目的是评估在随机对照试验（RCT）中使用太阳紫外线（UV）辐射产生25（OH）D浓度变化的可行性。在该RCT中测试的干预措施是有监督地每周三天，每天三天暴露于一种标准的红斑剂量（SED; 100 J m -2）的太阳紫外线辐射下，三周内没有衣服覆盖身体表面积的35％。来自澳大利亚布里斯班的36名白皙（II型和III型皮肤）室内工人被随机分为干预组（n= 16）或对照组（n = 20）；后者没有接受任何有监督的日光照射。我们要求两组在研究期间都使用防晒霜，并尽量减少在户外的时间。我们在基线时，在为期三周的干预期间每周一次以及在干预结束后的四个星期收集血液样本。在干预期间，使用聚砜徽章测量的累积紫外线辐射暴露在干预组中高于对照组（中位数为8 vs. 4 SED，p = 0.14）。三周后，干预组的平均血清25（OH）D浓度从60 nmol l -1增加到65 nmol l -1，从55 nmol L -1增加到57 nmol l -1在对照组中。调整基线25（OH）D后，干预阶段每周的平均变化与对照组相比无显着差异（0.7 vs. 0.3; p = 0.35）。在随访期间这种差异没有得到维持。需要进行大范围的现场试验，以告知政策要增加25（OH）D的浓度需要多少自然阳光照射。该飞行员确定了在设计此类试验时需要考虑的关键问题。
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