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Interaction of 5-hydroxy-l-tryptophan and negative dietary cation-anion difference on calcium homeostasis in multiparous peripartum dairy cows
Journal of Dairy Science ( IF 3.7 ) Pub Date : 2018-03-28 , DOI: 10.3168/jds.2017-13938
C.J. Slater , E.L. Endres , S.R. Weaver , A.A. Cheng , M.R. Lauber , S.F. Endres , E. Olstad , A. DeBruin , P.M. Crump , E. Block , L.L. Hernandez

Hypocalcemia affects almost 50% of all dairy cows. Our laboratory has previously demonstrated that infusions of the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP) increase circulating calcium concentrations in the Holstein transition cow. It is unknown whether feeding a negative DCAD diet alters the relationship between 5-HTP and hypocalcemia. The main objective of this study was to determine whether feeding a negative dietary cation-anion difference (−DCAD) diet before calving in conjunction with 5-HTP treatment could further diminish the magnitude of hypocalcemia at the time of calving. We used a randomized complete block design with a 2 × 2 factorial arrangement. Thirty-one multiparous Holstein cows were fed either a positive (+13 mEq/100 g) or negative (−13 mEq/100 g) DCAD diet 21 d before parturition and were intravenously infused daily with saline or 5-HTP (1 mg/kg) starting 7 d before the estimated date of parturition. Cows were blocked by parity and were randomly assigned to 1 of 4 treatment groups: positive DCAD plus saline, positive DCAD plus 5-HTP, negative DCAD plus saline, and negative DCAD plus 5-HTP, resulting in n = 8 per group. Total calcium (tCa), ionized calcium (iCa), and feed intake were recorded. The iCa was elevated prepartum in the −DCAD/5-HTP group compared with the other treatment groups as well as on d 0 and 1 postpartum. Although differences in tCa were not significant across the pre- or postpartum periods, tCa was numerically higher on d 0 and significantly higher on d 1 in −DCAD/5-HTP cows compared with all other groups. Prepartum the −DCAD/5-HTP treatment group ate less than the other treatment groups; however, postpartum dry matter intake differences were not significant. These findings demonstrate that feeding a −DCAD diet in conjunction with 5-HTP prepartum can increase postpartum circulating iCa concentrations and therefore diminish the magnitude of hypocalcemia at the time of parturition.



中文翻译:

5-羟基-1-色氨酸与负性饮食阳离子负离子差异对产前围产期奶牛钙动态平衡的影响

低血钙症影响几乎所有奶牛的50%。我们的实验室已先前证明血清素前体5-羟基的是输注-色氨酸(5-HTP)增加荷斯坦奶牛的循环钙浓度。喂养DCAD饮食阴性是否会改变5-HTP与低血钙之间的关系还不得而知。这项研究的主要目的是确定在产犊前与5-HTP治疗联合饲喂负的饮食阳离子负离子差异(-DCAD)饮食是否可以进一步减少产犊时低钙血症的程度。我们使用2×2析因排列的随机完整块设计。在分娩前21天,对31只多头荷斯坦奶牛饲喂正(+13 mEq / 100 g)或负(−13 mEq / 100 g)DCAD日粮,并每天静脉输注生理盐水或5-HTP(1 mg /公斤)在预计分娩日期前7天开始。母牛被胎次所阻断,被随机分配到4个治疗组中的1个:DCAD阳性加生理盐水,DCAD阳性加5-HTP阳性,DCAD阴性加生理盐水和DCAD加上5-HTP阴性,每组n = 8。记录总钙(tCa),离子钙(iCa)和采食量。与其他治疗组以及产后第0天和第1天相比,−DCAD / 5-HTP组的产前iCa升高。尽管在产前或产后期间tCa的差异不显着,但与所有其他组相比,-DCAD / 5-HTP奶牛的tCa在d 0时数值更高,在d 1时数值更高。产前−DCAD / 5-HTP治疗组的饮食少于其他治疗组;但是,产后干物质摄入差异不显着。

更新日期:2018-03-29
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