Detoxification reaction of chloropicrin in the human body with biological thiols was selected for detection of chloropicrin in the air. The consumption of free sulfhydryl group in biological thiols by chloropicrin is colorimetrically detectable with the addition of the Ellman’s reagent. In this study, glutathione, N-acetyl-l-cysteine, l-homocysteine, cysteamine, and thioglycolic acid were tested as sensing agents for chloropicrin vapor detection in ppb concentration range. The reactivity of the selected biological thiols was investigated based on both their redox properties and the nucleophilic strength of the sulfhydryl groups. Nylon-6 nanofibrous membrane and an organic solvent were used as a sensor matrix and a vapor sorbent, respectively, to provide solid supports with ultrahigh surface area and enhanced adsorption to chloropicrin vapor. The tunable sensitivity and detection range by using different biological thiols was achieved on the sensors due to the different reactivity of thiols toward chloropicrin.

中文翻译：

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基于生物硫醇的解毒反应，对尼龙-6纳米纤维膜上的氯霉素蒸气进行灵敏度可调比色检测。

选择了人体中的氯化苦与生物硫醇的解毒反应，以检测空气中的氯化苦。通过添加Ellman试剂可比色检测氯甲基吡啶对生物硫醇中游离巯基的消耗。在这项研究中，谷胱甘肽N-乙酰-1-半胱氨酸l测试了高纯半胱氨酸，半胱胺和巯基乙酸作为ppb浓度范围内的氯化苦蒸气检测的传感剂。基于它们的氧化还原特性和巯基的亲核强度，研究了所选生物硫醇的反应性。尼龙6纳米纤维膜和有机溶剂分别用作传感器基质和蒸气吸附剂，以提供具有超高表面积和增强的对氯比克林蒸气的吸附的固体载体。通过使用不同的生物硫醇，在传感器上实现了可调节的灵敏度和检测范围，这是由于硫醇对氯吡喃的反应性不同。