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Metal-free trifluoromethylthiolation of arenediazonium salts with Me4NSCF3
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2018-03-27 , DOI: 10.1016/j.jfluchem.2018.03.011
Giulia Bertoli , Benjamin Exner , Mathies V. Evers , Kristina Tschulik , Lukas J. Gooßen

A metal-free entry to the pharmaceutically meaningful substrate class of trifluoromethyl thioethers has been developed starting from widely available arenediazonium salts and commercially available Me4N+SCF3. This reaction proceeds within one hour at 0 °C and is applicable to a wide range of functionalized substrates.



中文翻译:

Me 4 NSCF 3对苯二氮杂鎓盐进行无金属三氟甲基硫醇化

无金属进入该药学有意义基板类三氟甲基硫醚的已开发从广泛可得的盐芳基重氮开始和市售我4 Ñ + SCF 3 - 。该反应在0°C下在一小时内进行,适用于多种功能化底物。

更新日期:2018-03-27
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