A new cladosporol derivative, 2-chloro-cladosporol D (6), was isolated together with known cladosporol (1), cladosporols B–D (2–4), and cladosporol F (5) from the culture broth of plant-associated Cladosporium sp. TMPU1621. The structure of 6 was elucidated from spectroscopic analyses including NMR and MS data. The productivity of 6 increased in 3% NaCl-supplemented medium; therefore, fermentation of the producing fungus TMPU1621 with 3% NaBr was investigated, leading to the induced production of a new halogenated cladosporol, 2-bromo-cladosporol D (7). Compound 2 showed the lowest MIC values of 3.13 and 12.5 μg/mL against two MRSA strains, ATCC43300 and ATCC700698, respectively.

一个新的cladosporol衍生物，2-氯cladosporol d（6）后，用公知的cladosporol（一起分离1），cladosporols B-d（2 - 4，和cladosporol F（）5从植物相关的培养液）枝孢sp。TMPU1621。从包括NMR和MS数据的光谱分析中阐明了6的结构。在补充了3％NaCl的培养基中，6的生产率提高了；因此，研究了用3％NaBr发酵生产真菌TMPU1621的方法，从而诱导了新的卤代克拉多酚2-溴-cladosporol D的诱导生产（7）。化合物2 对两种MRSA菌株ATCC43300和ATCC700698的最低MIC值分别为3.13和12.5μg/ mL。