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Halogenated cladosporols produced by the sodium halide-supplemented fermentation of the plant-associated fungus Cladosporium sp. TMPU1621
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-03-28 , DOI: 10.1016/j.tetlet.2018.03.082
Hiroyuki Yamazaki , Akiho Yagi , Masanari Akaishi , Ryota Kirikoshi , Ohgi Takahashi , Tatsuki Abe , Satomi Chiba , Kenta Takahashi , Natsuki Iwakura , Michio Namikoshi , Ryuji Uchida

A new cladosporol derivative, 2-chloro-cladosporol D (6), was isolated together with known cladosporol (1), cladosporols B–D (24), and cladosporol F (5) from the culture broth of plant-associated Cladosporium sp. TMPU1621. The structure of 6 was elucidated from spectroscopic analyses including NMR and MS data. The productivity of 6 increased in 3% NaCl-supplemented medium; therefore, fermentation of the producing fungus TMPU1621 with 3% NaBr was investigated, leading to the induced production of a new halogenated cladosporol, 2-bromo-cladosporol D (7). Compound 2 showed the lowest MIC values of 3.13 and 12.5 μg/mL against two MRSA strains, ATCC43300 and ATCC700698, respectively.



中文翻译:

通过卤化钠补充植物相关真菌Cladosporium sp。的发酵而产生的卤代cladosporol 。TMPU1621

一个新的cladosporol衍生物,2-氯cladosporol d(6)后,用公知的cladosporol(一起分离1),cladosporols B-d(2 - 4,和cladosporol F()5从植物相关的培养液)枝孢sp。TMPU1621。从包括NMR和MS数据的光谱分析中阐明了6的结构。在补充了3%NaCl的培养基中,6的生产率提高了;因此,研究了用3%NaBr发酵生产真菌TMPU1621的方法,从而诱导了新的卤代克拉多酚2-溴-cladosporol D的诱导生产(7)。化合物2 对两种MRSA菌株ATCC43300和ATCC700698的最低MIC值分别为3.13和12.5μg/ mL。

更新日期:2018-03-28
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