UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry,Organic Process Research & Development

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UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-03-28 00:00:00 , DOI: 10.1021/acs.oprd.8b00037
Charlotte A. Clark , Darren S. Lee , Stephen J. Pickering , Martyn Poliakoff , Michael W. George ₁

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We report the use of a simple rotary evaporator as a semi-continuous UV photochemical reactor. By generation of a thin film from the rotation of a flask, better light penetration is achieved, and in this work we used high-power Hg lamps to enable the direct irradiation of molecules with UV light. The intramolecular [2 + 2] photocycloaddition of Cookson’s dione and the intermolecular [2 + 2] photocycloaddition of maleimide with 1-hexyne were used as test reactions to examine the effectiveness of this reactor. High productivities, equivalent to 210 g h^–1, were obtained for the simple intramolecular reaction, demonstrating the scalability of the reactor. The effects of flask size, reaction mixture volume, and use of borosilicate or quartz glassware were also investigated.

中文翻译：

UV PhotoVap：演示如何将基于常规旋转蒸发仪的简单多功能反应器用于UV光化学

我们报告了使用简单的旋转蒸发仪作为半连续UV光化学反应器。通过烧瓶旋转产生薄膜，可以实现更好的光穿透性，在这项工作中，我们使用了大功率的汞灯，可以用紫外线直接照射分子。库克森二酮的分子内[2 + 2]光环加成反应和马来酰亚胺与1-己炔的分子间[2 + 2]光环加成反应用作测试反应器，以检验该反应器的有效性。对于简单的分子内反应，获得了相当于210 gh ^–1的高生产率，证明了反应器的可扩展性。还研究了烧瓶尺寸，反应混合物体积以及硼硅酸盐或石英玻璃器皿的使用的影响。

更新日期：2018-03-28

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