The Ugi adducts prepared from propiolic acids, propargylamines, indole-2-carbaldehydes, and isocyanides were utilized to assemble polycyclic indole-fused frameworks via two consecutive carbocyclizations involving triple bonds. First, the peptidyl position of Ugi adduct underwent potassium carbonate-mediated cyclization onto the triple bond derived from propiolic acid. Then, the position 3 of indole core engaged into gold-catalyzed cyclization onto the propargylamine-originated alkyne, completing the construction of polycyclic core.

中文翻译：

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在Ugi后转化中区分炔烃反应性：获得多环吲哚融合的骨架

由丙酸，炔丙基胺，吲哚-2-甲醛和异氰酸酯制备的Ugi加合物用于通过两个连续的涉及三键的碳环化来组装多环吲哚稠合的骨架。首先，Ugi加合物的肽基位置经历了碳酸钾介导的环化作用，该环化作用源自丙酸的三键上。然后，吲哚核的位置3参与金催化的炔丙基胺来源的炔烃的环化反应，从而完成了多环核的构建。