The exploration of azide-enolate cycloaddition in the synthesis of novel Rufinamide analogs is reported for the first time. A very simple procedure involving the use of β-ketonitriles as dipolarophiles afforded 5-aril/heteroayl Rufinamide derivatives in two steps.

中文翻译：

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在合成新型Rufinamide类似物中探索叠氮化物-烯酸酯环加成反应

首次报道了在新型Rufinamide类似物的合成中对叠氮化物-烯酸酯环加成的探索。一个非常简单的程序，涉及使用β-乙腈作为双极性亲和剂，分两步提供了5-芳基/杂油基Rufinamide衍生物。