Butyrate, the fermentation end product of gut microbiota in the colon, is known for its antitumor effects, but the mechanisms remained to be defined. α‐ketoglutarate (α‐KG) mediates DNA demethylation and aberrant epigenetic modifications are associated with carcinogenesis. The objectives of this study are to evaluate the effects of butyrate on α‐KG mediated epigenetic modification in colorectal adenocarcinoma HT‐29 and Caco‐2 cells.

中文翻译：

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丁酸通过增强错配修复基因的α-酮戊二酸依赖性DNA脱甲基作用抑制大肠癌发生的指标

丁酸盐是结肠中肠道菌群的发酵终产物，因其抗肿瘤作用而闻名，但其机理尚待确定。α-酮戊二酸（α-KG）介导DNA脱甲基，异常的表观遗传修饰与癌变有关。这项研究的目的是评估丁酸对大肠腺癌HT-29和Caco-2细胞中α-KG介导的表观遗传修饰的影响。