Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking†‡,Chemical Communications

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Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking†‡
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-26 00:00:00 , DOI: 10.1039/c8cc01639a
X Shang ₁ , Y Chen , N Wang , W Niu , J Guo

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We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein–protein crosslinking in the presence of a large excess of free nucleophile.

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