Organic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugs,Journal of Food and Drug Analysis

当前位置： X-MOL 学术 › J. Food Drug Anal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Organic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugs
Journal of Food and Drug Analysis ( IF 2.6 ) Pub Date : 2018-04-01 , DOI: 10.1016/j.jfda.2018.03.002
Raymond E Lai ₁ , Christopher E Jay ₁ , Douglas H Sweet ₁

Affiliation

Many drugs, hormones, components of herbal medicines, environmental pesticides and toxins are Solute Carrier family 22 (SLC22) substrates. The last twenty years has seen great progress in determining SLC22 tissue expression profiles, membrane localization, energetics, substrate profiles and biopharmaceutical significance. However, much still remains to be answered in terms of SLC22 family member's roles in 'normal' physiology as compared to pathophysiological states, as well as in drug interactions that impact pharmacokinetics, efficacy and toxicity. This review begins with a brief synopsis of SLC22 family discovery, function and tissue expression. Subsequent sections provide examples establishing a role for SLC22 transporters in food-drug, herbal supplement-drug, endogenous substrate-drug and drug-drug interactions.

中文翻译：

有机溶质载体 22 (SLC22) 家族：与食物、草药/膳食补充剂、内源性化合物和药物相互作用的潜力

许多药物、激素、草药成分、环境杀虫剂和毒素都是溶质载体家族 22 (SLC22) 的底物。过去二十年来，在确定 SLC22 组织表达谱、膜定位、能量学、底物谱和生物制药意义方面取得了巨大进展。然而，与病理生理状态相比，SLC22 家族成员在“正常”生理学中的作用以及影响药代动力学、功效和毒性的药物相互作用方面仍有许多问题需要回答。这篇综述首先简要介绍了 SLC22 家族的发现、功能和组织表达。随后的部分提供了建立 SLC22 转运蛋白在食品-药物、草药补充剂-药物、内源性底物-药物和药物-药物相互作用中的作用的示例。

更新日期：2018-04-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11