Objective

There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects’ lipid profiles. Our objective was to characterize lipoprotein size, particle and subclass concentration using ¹H NMR in MHO women after two years of weight loss with a hypocaloric Mediterranean diet and physical exercise.

Methods

115 non-diabetic women (aged 35–55 years) with a body mass index (BMI) of 30–40 kg/m² and ≤1 of the following criteria: blood pressure ≥135/85 mmHg, fasting plasma glucose ≥100 mg/dL, HDL cholesterol ≤50 mg/dL and triglycerides ≥150 mg/dL were included. After two years of intensive lifestyle modification (Mediterranean diet and physical exercise), they were classified according to their weight loss: <5%, ≥5%-<10% and ≥10%. Lipoprotein size, particle and subclass concentrations were measured using ¹H NMR.

Results

The final population, after dropouts, were 67 women (age: 44.5 ± 3.7 years, BMI: 36.3 ± 4.7 kg/m²), of whom 23 (38.3%) lost <5%, and 22 (36.7%), lost ≥5% to <10% and ≥10% of baseline body weight, respectively. The lipid profile showed no significant changes after intervention, especially in small LDL particles or in production of HDL. The diameter of LDL and HDL particles did not change after two years of a Mediterranean diet and physical exercise.

Conclusion

These results indicate that intensive lifestyle modification does not produce significant changes in the lipid profile of MHO women. Levels of more atherogenic or atheroprotective particles did not change after two years, despite the intervention.

中文翻译：

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通过核磁共振波谱（¹ H NMR）测量，地中海饮食和体育锻炼对代谢健康的肥胖女性脂质谱的影响

客观的

在建立定义代谢健康肥胖（MHO）受试者的生化参数方面缺乏共识。实际上，大多数研究不包括受试者的脂质分布。我们的目标是使用低热量的地中海饮食和体育锻炼，在减肥两年后，使用¹ H NMR表征MHO妇女的脂蛋白大小，颗粒和亚类浓度。

方法

115位体重指数（BMI）为30–40 kg / m ²且≤1且符合以下标准的非糖尿病女性（年龄35–55岁）：血压≥135/ 85 mmHg，空腹血糖≥100mg / dL，HDL胆固醇≤50mg / dL和甘油三酸酯≥150mg / dL。经过两年的强烈生活方式修改（地中海饮食和体育锻炼），他们根据体重减轻分为：<5％，≥5％-<10％和≥10％。使用¹ H NMR测量脂蛋白大小，颗粒和亚类浓度。

结果

辍学后的最终人口为67名妇女（年龄：44.5±3.7岁，BMI：36.3±4.7 kg / m ²），其中23名（38.3％）的体重下降<5％，22名（36.7％）的体重下降≥分别为基线体重的5％至<10％和≥10％。干预后血脂谱无明显变化，特别是在小LDL颗粒或HDL产生中。经过两年的地中海饮食和体育锻炼，LDL和HDL颗粒的直径没有变化。

结论

这些结果表明，强烈的生活方式改变不会使MHO妇女的脂质分布发生显着变化。尽管进行了干预，但两年后没有发生更多的致动脉粥样硬化或抗动脉粥样硬化颗粒物的水平没有变化。