We accomplished a divergent synthesis of sudachitin (2), a polymethoxyflavone isolated from citrus fruits, and six derivatives from acetophenone 9, which was an intermediate in our previous synthesis of nobiletin (1). Compound 2 enhanced glucose-induced insulin secretion in INS-1D cells, but was less potent than 1. Compared with 1, compound 2 and two derivatives were more potent inhibitors of cAMP-specific phosphodiesterase.

中文翻译：

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聚甲氧基黄酮Sudachitin及其衍生物的简捷合成及生物学评价

我们完成了sudachitin（2）（一种从柑橘类水果中分离出来的聚甲氧基黄酮）和六种苯乙酮9衍生物的衍生物的多样化合成，这是我们之前合成nobiletin（1）的中间体。化合物2增强了INS-1D细胞中葡萄糖诱导的胰岛素分泌，但作用强度低于1。与1相比，化合物2和两个衍生物是cAMP特异性磷酸二酯酶的更有效抑制剂。