Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study,Molecular Nutrition & Food Research

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Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-04-20 , DOI: 10.1002/mnfr.201700960
Irene Roncero-Ramos _{1,

2} , Oriol A. Rangel-Zuñiga _{1,

2} , Javier Lopez-Moreno _{1,

2} , Juan F. Alcala-Diaz _{1,

2} , Pablo Perez-Martinez _{1,

2} , Rosa Jimenez-Lucena _{1,

2} , Justo P. Castaño _{2,

3} , Helen M. Roche ₄ , Javier Delgado-Lista _{1,

2} , Jose M. Ordovas _{5,

6,

7} , Antonio Camargo _{1,

2} , Jose Lopez-Miranda _{1,

2}

Affiliation

Insulin resistance (IR) and chronic low‐grade inflammation are hallmarks of type 2 diabetes mellitus (T2DM). The “NOD‐like receptor pyrin domain containing‐3” (NLRP3) inflammasome component of innate immunity is a metabolic stress sensor modulated by dietary and genetics factors. The aim of this study was to evaluate the effects of the consumption of two diets for 3 years, Mediterranean (Med) and low fat, on glucose homeostasis in the 1002 coronary heart disease patients of the CORDIOPREV study, according to a genetic variant of NLRP3 inflammasome.

中文翻译：

地中海饮食，葡萄糖稳态和炎症性遗传变异：CORDIOPREV研究

胰岛素抵抗（IR）和慢性低度炎症是2型糖尿病（T2DM）的标志。先天免疫的“含NOD的受体含3个吡喃结构域”（NLRP3）炎性体成分是由饮食和遗传因素调节的代谢应激传感器。这项研究的目的是根据NLRP3的遗传变异性，评估CORDIOPREV研究的1002冠心病患者食用地中海（Med）和低脂两种饮食3年对葡萄糖稳态的影响。炎性体。

更新日期：2018-04-20

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