Liver ailments have become one of the most health-threatening problems, looking for safe and effective natural liver protection agents is one of future directions. Flavonoids are widely found in traditional Chinese medicinal (TCM) herbs, some of which have significant protective effects on liver injury caused by various factors. From the recent research progress, it is concluded that flavonoids can enhance the antioxidant functions of liver by increasing the level of superoxide dismutase, glutathione s-transferase and glutathione peroxidase, improve insulin sensitivity and inhibit hepatic stellate cell activation by regulating the activities of the enzymes such as heme oxygenase-1, cytochrome P450 and telomerase, reduce inflammatory reaction by restraining the expression of tumor necrosis factor-α, interferon-γ and interleukin-6, and mediate apoptosis and autophagy by controlling the pathways of genes-p 53-genetics, nuclear factor κB and phosphatidylinositol 3-kinase/protein kinase B signaling, which will provide an alternative way for the treatment of liver injury.

肝脏疾病已成为最威胁健康的问题之一，寻找安全有效的天然肝保护剂是未来的方向之一。黄酮类化合物广泛存在于传统中药（TCM）中，其中一些对多种因素引起的肝损伤具有显着的保护作用。从最近的研究进展可以得出结论，黄酮类化合物可以通过增加超氧化物歧化酶，谷胱甘肽S-转移酶和谷胱甘肽过氧化物酶的水平来增强肝脏的抗氧化功能，改善胰岛素敏感性，并通过调节酶的活性来抑制肝星状细胞的活化。例如血红素加氧酶-1，细胞色素P450和端粒酶，通过抑制肿瘤坏死因子-α，干扰素-γ和白介素-6的表达来减轻炎症反应，