Objective

To conduct a systematic review, including meta-analysis, of published randomised controlled trials (RCTs) of cumin to determine the effect on anthropometric and metabolic indices in overweight and/or type 2 diabetics, relative to controls.

Methods

Studies were identified by a search of electronic databases before December 2017. Combined and stratified analyses were used.

Results

Seven trials were identified, and data from 412 subjects were included. Pooled analysis showed improvements in bodyweight, body mass index (BMI) and fasting blood glucose (FBG) by −1.74 kg, −0.67 kg/m² and −17.82 mg/dL respectively. Significant findings were also observed in triglycerides (TG) [WMD: −21.23 (95% CI: −37.64 to −4.82; P < 0.001, I² = 92%)] and HDL-c (high-density lipoprotein cholesterol) [WMD: 4.16 (95%CI: 3.30, 5.01; P < 0.001, I² = 82%)] following cumin intake. No changes were found in controls.

Conclusions

Cumin improves anthropometric and metabolic indices in overweight and/or type 2 diabetic subjects. The changes were related to the clinical condition and quality assessment.

中文翻译：

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小茴香（Cuminum cyminim L.）摄入量对超重和2型糖尿病患者代谢和人体测量指标的荟萃分析

客观的

对已进行的孜然随机对照试验（RCT）进行系统评价，包括荟萃分析，以确定相对于对照组的超重和/或2型糖尿病患者对人体测量和代谢指标的影响。

方法

通过在2017年12月之前搜索电子数据库来识别研究。使用了组合和分层分析。

结果

确定了七项试验，并纳入了412名受试者的数据。汇总分析显示，体重，体重指数（BMI）和空腹血糖（FBG）分别提高了-1.74 kg，-0.67 kg / m ²和-17.82 mg / dL。在甘油三酸酯（TG）[WMD：-21.23（95％CI：−37.64至−4.82； P <0.001，I ² = 92％）]和HDL-c（高密度脂蛋白胆固醇）[WMD]中也观察到了重要发现。： 小茴香摄入后4.16（95％CI：3.30，5.01; P <0.001，I ² = 82％）]。在控件中未找到任何更改。

结论

孜然改善超重和/或2型糖尿病受试者的人体测量和代谢指标。这些变化与临床状况和质量评估有关。