Helicobacter pylori (H. pylori) plays a causal role in chronic gastritis, peptic ulcer and gastric cancer. Antibiotic resistance and side effects of therapy have led to research for new candidates.

Susceptibility and virulence factors were studied in H. pylori 12 clinical isolates. Agrimonia eupatoria L. (Ag), Fragaria vesca (Fv) extracts and a Fv ellagitannin-enriched fraction (Fve) activity were tested against these isolates.

Ag, Fv extracts and Fve presented activity against H. pylori multi-resistant and virulent. Fve demonstrated the best activity (5 mg/mL inhibited 67% of isolates), follow by Fv (12.5 mg/mL inhibited 58%) and by Ag (25 mg/mL inhibited 40%).

This is the first report of Fv extract and Fve fraction activity on H. pylori isolates. These activity and that of Ag were independently of the different patterns of virulence and susceptibility, suggesting potential of these plants as new natural drugs or as bioactive agents in association with antibiotic therapy.

幽门螺杆菌（H. pylori）在慢性胃炎，消化性溃疡和胃癌中起因果作用。抗生素耐药性和治疗副作用已导致新候选人的研究。

在幽门螺杆菌12临床分离株中研究了敏感性和毒力因子。针对这些分离物测试了非洲龙胆（Agrimonia eupatoria L.）（Ag），非洲草莓（Fvaria vesca（Fv））提取物和富含鞣花单宁的Fv活性（Fve）。

Ag，Fv提取物和Fve表现出对幽门螺杆菌的多重耐药和强毒活性。Fve表现出最好的活性（5 mg / mL抑制了67％的分离物），其次是Fv（12.5 mg / mL抑制了58％）和Ag（25 mg / mL抑制了40％）。

这是关于幽门螺杆菌分离株的Fv提取物和Fve组分活性的首次报道。这些活性和Ag的活性独立于毒力和敏感性的不同模式，表明这些植物作为新的天然药物或与抗生素治疗有关的生物活性剂的潜力。