Sweet Switch: Sugar-Responsive Bioactive Surfaces Based on Dynamic Covalent Bonding,ACS Applied Materials & Interfaces

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Sweet Switch: Sugar-Responsive Bioactive Surfaces Based on Dynamic Covalent Bonding
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1021/acsami.7b18166
Wenjun Zhan ₁ , Yangcui Qu ₁ , Ting Wei ₁ , Changming Hu ₁ , Yue Pan ₁ , Qian Yu ₁ , Hong Chen ₁

Affiliation

Smart bioactive surfaces that can modulate interactions with biological systems are of great interest. In this work, a surface with switchable bioactivity in response to sugars has been developed. It is based on dynamic covalent bonding between phenylboronic acid (PBA) and secondary hydroxyls on the “wide” rim of β-cyclodextrin (β-CD). The system reported consists of gold surface modified with PBA-containing polymer brushes and a series of functional β-CD derivatives conjugated to diverse bioactive ligands (CD-X). CD-X molecules are attached to the surface to give specified bioactivity such as capture of a specific protein or killing of attached bacteria. Subsequent treatment with cis-diol containing biomolecules having high affinity for PBA (e.g. fructose) leads to the release of CD-X together with the captured proteins, killed bacteria, and so forth from the surface. The surface bioactivity is thereby “turned off”. Effectively, this constitutes an on–off bioactivity switch in a mild and noninvasive way, which has the potential in the design of dynamic bioactive surfaces for biomedical applications.

中文翻译：

Sweet Switch：基于动态共价键的糖响应性生物活性表面

可以调节与生物系统相互作用的智能生物活性表面备受关注。在这项工作中，已经开发了具有可响应于糖的生物活性的表面。它基于苯硼酸（PBA）和β-环糊精（β-CD）“宽”边缘上的仲羟基之间的动态共价键。报告的系统由用含PBA的聚合物刷修饰的金表面和与各种生物活性配体（CD-X）共轭的一系列功能性β-CD衍生物组成。CD-X分子附着在表面上，具有特定的生物活性，例如捕获特定蛋白质或杀死附着的细菌。随后使用对PBA具有高亲和力的含顺式二醇的生物分子（例如果糖）进行处理会导致CD-X与捕获的蛋白质，被杀死的细菌，等等。由此，表面生物活性被“关闭”。有效地，这以温和且无创的方式构成了开关式生物活性开关，这在设计用于生物医学应用的动态生物活性表面时具有潜力。

更新日期：2018-03-13

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