Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. 3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) database (1973-2017). White people account for 79.1% with median age of 57 years without predominance in any gender. Significant disease specific survival (DSS) and overall survival (OS) were found differentiated in age, T stage, N stage, M stage, AJCC stage, SEER historic stage, tumor locations, surgery, and pathologic grade. In the multivariate Cox analysis, the age >64 years (for DSS, P < 0.001 and for OS, P < 0.001; Reference age ≤64 years), AJCC stage III (for DSS, P = 0.006 and for OS, P = 0.04; Reference: AJCC stage I), and non-surgical treatment (for DSS, P < 0.001 and for OS, P < 0.001; Reference: surgery) were independently associated with worse DSS and OS. In brief, our study demonstrated that SCS mostly found in white people at fifth to seventh decades of life without gender predilection. The patient's age, AJCC stage, tumor location and surgery were independent prognostic indicators for both DSS and OS of SCS.

中文翻译：

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梭形细胞肉瘤：基于SEER人群的分析。

由于研究人群的巨大局限性，尚未全面探讨纺锤状细胞肉瘤（SCS）。在这项研究中，我们调查了SCS的临床特征和疾病的预后因素。从监测，流行病学和最终结果（SEER）数据库（1973-2017）中识别并提取了3299例SCS病例。白人占79.1％，中位年龄为57岁，没有任何性别优势。发现在年龄，T期，N期，M期，AJCC期，SEER历史期，肿瘤位置，手术和病理分级方面存在显着的疾病特异性存活率（DSS）和总体存活率（OS）。在多变量Cox分析中，年龄> 64岁（对于DSS，P <0.001，对于OS，P <0.001；参考年龄≤64岁），AJCC第三阶段（对于DSS，P = 0.006，对于OS，P = 0.04 ; 参考：AJCC I期）和非手术治疗（对于DSS，P <0.001，对于OS，P <0.001；参考：手术）分别与较差的DSS和OS相关。简而言之，我们的研究表明，SCS多见于年龄在五到七十岁的白人中，没有性别偏爱。患者的年龄，AJCC分期，肿瘤位置和手术是DSS和SCS OS的独立预后指标。