Foldamers wave to the ribosome

Foldamers wave to the ribosome, Published online: 22 March 2018; doi:10.1038/s41557-018-0036-5

Ribosomes have now been shown to accept certain initiator tRNAs acylated with aromatic foldamer–dipeptides thereby enabling the translation of a peptide or protein with a short aromatic foldamer at the N-terminus. Some foldamer–peptide hybrids could be cyclized to generate macrocycles that present conformationally restricted peptide loops.

中文翻译：

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Foldamers向核糖体挥手

Foldamers向核糖体挥手

Foldamers向核糖体挥手，在线发布：2018年3月22日; doi：10.1038 / s41557-018-0036-5

现已显示，核糖体可以接受某些被芳香族foldamer-deptides酰化的起始tRNA，从而能够在N末端用短芳香族foldamer进行肽或蛋白质的翻译。一些foldamer-peptide杂种可以被环化以产生大环，这些大环呈现出构象受限的肽环。