Organ transplantation is the most effective therapy for patients with end-stage disease. Preservation solutions and techniques are crucial for donor organ quality, which is directly related to morbidity and survival after transplantation. Currently, static cold storage (SCS) is the standard method for organ preservation. However, preservation time with SCS is limited as prolonged cold storage increases the risk of early graft dysfunction that contributes to chronic complications. Furthermore, the growing demand for the use of marginal donor organs requires methods for organ assessment and repair. Machine perfusion has resurfaced and dominates current research on organ preservation. It is credited to its dynamic nature and physiological-like environment. The development of more sophisticated machine perfusion techniques and better perfusates may lead to organ repair/reconditioning. This review describes the history of organ preservation, summarizes the progresses that has been made to date, and discusses future directions for organ preservation.

中文翻译：

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器官保存：从过去到未来。

器官移植是终末期疾病患者最有效的疗法。保存方法和技术对于供体器官质量至关重要，这与移植后的发病率和存活率直接相关。当前，静态冷藏（SCS）是器官保存的标准方法。但是，SCS的保存时间有限，因为长时间的冷藏会增加早期移植物功能障碍的风险，从而导致慢性并发症。此外，对使用边缘供体器官的需求不断增长，需要进行器官评估和修复的方法。机器灌注已经浮出水面，并支配了目前有关器官保存的研究。它因其动态特性和类似生理的环境而著称。更先进的机器灌注技术和更好的灌注液的发展可能导致器官修复/修复。这篇综述描述了器官保存的历史，总结了迄今为止取得的进展，并讨论了器官保存的未来方向。