Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles,Faraday Discussions

当前位置： X-MOL 学术 › Faraday Discuss. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles
Faraday Discussions ( IF 3.3 ) Pub Date : 2018-03-22 , DOI: 10.1039/c8fd00022k
Kazushi Kinbara _{1,

2,

3,

4} , Kaori Umetsu _{4,

5,

6,

7} , Hiroki Sonobe _{1,

2,

3,

4} , Takahiro Muraoka _{1,

2,

3,

4} , Naofumi Shimokawa _{4,

8,

9,

10} , Masahiro Takagi _{4,

8,

9,

10}

Affiliation

A series of triblock amphiphilic molecules bearing hydrophilic PEG chains at both ends of the long aromatic hydrophobic moieties were obtained serendipitously. The molecules involve linearly connected diarylethyne and diarylbutadiyne units, which show characteristic emissions upon excitation by UV light. These emissions showed red-shifts upon an increase in the solvent polarity, where the shifts are larger for the molecules with longer aromatic moieties. The distribution of these molecules in phase-separated membranes consisting of DOPC/DPPC/cholesterol was studied by fluorescence microscopy. It was found that most compounds, except for that with the longest hydrophobic unit, were selectively distributed in the Ld phase consisting mainly of DOPC. Interestingly, some of them were suggested to encourage delocalization of cholesterol in both the Lo and Ld phases.

中文翻译：

跨膜多嵌段两亲分子在相分离囊泡中的定位

偶然获得了一系列在长芳族疏水部分的两端带有亲水性PEG链的三嵌段两亲性分子。该分子包括线性连接的二芳基乙炔和二芳基丁二炔单元，它们在被紫外线激发时显示出特征性发射。随着溶剂极性的增加，这些发射物显示出红移，其中对于具有较长芳族部分的分子，该移变更大。通过荧光显微镜研究了这些分子在由DOPC / DPPC /胆固醇组成的相分离膜中的分布。发现除了具有最长的疏水单元的化合物以外，大多数化合物选择性地分布在主要由DOPC组成的Ld相中。有趣的是，

更新日期：2018-09-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11