A novel 5,6-diaryl-1,2,4-triazine thiazole derivatives (7a-7q) were synthesized and characterized by ¹H NMR and ¹³C NMR and evaluated for their α-glucosidase inhibitory activity. All tested compounds displayed good α-glucosidase inhibitory activity with IC₅₀ values ranging between 2.85 ± 0.13 and 14.19 ± 0.23 μM when compared to the standard drug acarbose (IC₅₀ = 817.38 ± 6.27 μM). Compound 7i (IC₅₀ = 2.85 ± 0.13 μM) exhibited the highest activity among this series of compounds. Molecular docking studies were carried out in order to investigate the binding mode of this class of compounds to α-glucosidase. This study showed that these 5,6-diaryl-1,2,4-triazine thiazole derivatives are a new class of α-glucosidase inhibitors.

合成了新颖的5,6-二芳基-1,2,4-三嗪噻唑衍生物（7a - 7q），并通过¹ H NMR和¹³ C NMR对其进行了表征，并评估了其对α-葡萄糖苷酶的抑制活性。与标准阿卡波糖（IC ₅₀  = 817.38±6.27μM）相比，所有测试化合物均显示出良好的α-葡萄糖苷酶抑制活性，IC ₅₀值在2.85±0.13和14.19± 0.23μM之间。化合物7i（IC ₅₀ = 2.85±0.13μM）在这一系列化合物中表现出最高的活性。为了研究这类化合物与α-葡萄糖苷酶的结合方式，进行了分子对接研究。该研究表明，这些5,6-二芳基-1,2,4-三嗪噻唑衍生物是一类新的α-葡萄糖苷酶抑制剂。