Efficacious Vaccine against Heroin Contaminated with Fentanyl,ACS Chemical Neuroscience

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Efficacious Vaccine against Heroin Contaminated with Fentanyl
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1021/acschemneuro.8b00079
Candy S. Hwang ₁ , Lauren C. Smith ₁ , Yoshihiro Natori ₁ , Beverly Ellis ₁ , Bin Zhou ₁ , Kim D. Janda ₁

Affiliation

The sharp increase in overdose deaths involving illicit opioid use has been declared a national crisis in the United States. This growing number of overdose deaths can in part be attributed to the increased frequency of fentanyl contamination in the United States heroin supply. To combat this growing trend, we designed a vaccine containing a mixture of heroin and fentanyl hapten-conjugates as a proof-of-concept immunotherapy targeting a combination of these drugs. Rodents immunized with the admixture vaccine showed drug retention in serum and reduced distribution in the brain after administration of an intravenous bolus of heroin coadministered with fentanyl (10% w/w). Moreover, the admixture vaccine performed as well as or better than individual immunoconjugate vaccines in antinociception behavioral models and recognized six other fentanyl analogues with nanomolar affinity. Taken together, these data highlight the potential of an admixture vaccine against heroin contaminated with fentanyl.

中文翻译：

对抗芬太尼污染的海洛因的有效疫苗

在美国，涉及非法使用阿片类药物的过量死亡急剧增加。过量死亡的增加数量部分归因于美国海洛因供应中芬太尼污染的频率增加。为了应对这种不断增长的趋势，我们设计了一种包含海洛因和芬太尼半抗原结合物的混合物的疫苗，作为针对这些药物组合的概念验证免疫疗法。用混合疫苗免疫的啮齿动物在静脉注射海洛因和芬太尼（10％w / w）后显示出药物在血清中的滞留和在大脑中的分布减少。而且，该混合疫苗在抗伤害感受行为模型中的性能优于或优于个别免疫缀合物疫苗，并识别出其他六种具有纳摩尔摩尔亲和力的芬太尼类似物。综上所述，这些数据突显了针对被芬太尼污染的海洛因的混合疫苗的潜力。

更新日期：2018-03-20

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