We detail the formation of a pilot multipharmaceutical-company–chemical-vendor Buying Group that successfully facilitated access to fluorinated building blocks of high interest to medicinal chemists for analog synthesis at significantly reduced prices. This exercise showed significant overlap in building block interests among the participants and suggests that creative approaches to access building blocks is of common interest to medicinal chemists and will be valuable as the challenges of drug discovery continue to call for more-highly-tuned drug candidates that can be synthesized quickly.

中文翻译：

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通过协作增加构建基块的访问

我们详细介绍了一个试验性的多药公司-化学供应商购买小组的组建，该小组成功地促进了药物化学家以显着降低的价格获得对氟化物基团的高度兴趣，以进行类似物合成。这项练习表明参与者之间在构建模块兴趣方面存在重大重叠，并且表明，访问构建模块的创新方法是药物化学家们共同感兴趣的，并且在药物发现的挑战继续要求对药物进行高度调整的候选药物方面将具有宝贵的价值。可以快速合成。