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Copper-Catalyzed Tandem Multi-Component Approach to 1,3-Oxazines at Room Temperature by Cross-Dehydrogenative Coupling Using Methanol as C1 Feedstock
Synlett ( IF 1.7 ) Pub Date : 2018-03-20 , DOI: 10.1055/s-0036-1591775
Paran Borpatra 1 , Mohit Deb 1 , Pranjal Baruah 1
Affiliation  

A copper(II)-catalyzed multi-component one-pot approach for the synthesis of 1,3-oxazines at room temperature is reported here. Methanol is used as the solvent as well as the carbon source. The methylene carbon of the oxazine product comes from methanol via formaldehyde. tert -Butyl hydroperoxide is used as the oxidant. The reaction uses an environmentally benign metal catalyst and oxidant. No inert atmosphere or precaution is required for the reaction. Most importantly, the reaction avoids the use of carcinogenic formaldehyde.

中文翻译:

铜催化串联多组分方法在室温下通过交叉脱氢偶联制备 1,3-恶嗪,使用甲醇作为 C1 原料

本文报道了一种铜 (II) 催化的多组分一锅法在室温下合成 1,3-恶嗪。甲醇用作溶剂和碳源。恶嗪产品的亚甲基碳来自甲醇经由甲醛。叔丁基过氧化氢用作氧化剂。该反应使用对环境无害的金属催化剂和氧化剂。该反应不需要惰性气氛或预防措施。最重要的是,该反应避免了致癌甲醛的使用。
更新日期:2018-03-20
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