Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR†,Chemical Communications

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Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-21 00:00:00 , DOI: 10.1039/c8cc01346b
M. E. Ward _{1,

2,

3,

4,

5} , M. A. Daniëls _{1,

2,

3,

4,

5} , E. C. van Kappel _{4,

6,

7,

8,

9} , M. M. Maurice _{4,

6,

7,

8,

9} , M. Baldus _{1,

2,

3,

4,

5}

Affiliation

We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.

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