Moving magnetoencephalography towards real-world applications with a wearable system,Nature

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Moving magnetoencephalography towards real-world applications with a wearable system
Nature ( IF 50.5 ) Pub Date : 2018-03-01 , DOI: 10.1038/nature26147
Elena Boto ₁ , Niall Holmes ₁ , James Leggett ₁ , Gillian Roberts ₁ , Vishal Shah ₂ , Sofie S Meyer _{3,

4} , Leonardo Duque Muñoz ₃ , Karen J Mullinger _{1,

5} , Tim M Tierney ₃ , Sven Bestmann _{3,

6} , Gareth R Barnes ₃ , Richard Bowtell ₁ , Matthew J Brookes ₁

Affiliation

Imaging human brain function with techniques such as magnetoencephalography typically requires a subject to perform tasks while their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessible to many people, and limits the experimental questions that can be addressed. For example, it has been difficult to apply neuroimaging to investigation of the neural substrates of cognitive development in babies and children, or to study processes in adults that require unconstrained head movement (such as spatial navigation). Here we describe a magnetoencephalography system that can be worn like a helmet, allowing free and natural movement during scanning. This is possible owing to the integration of quantum sensors, which do not rely on superconducting technology, with a system for nulling background magnetic fields. We demonstrate human electrophysiological measurement at millisecond resolution while subjects make natural movements, including head nodding, stretching, drinking and playing a ball game. Our results compare well to those of the current state-of-the-art, even when subjects make large head movements. The system opens up new possibilities for scanning any subject or patient group, with myriad applications such as characterization of the neurodevelopmental connectome, imaging subjects moving naturally in a virtual environment and investigating the pathophysiology of movement disorders.

中文翻译：

使用可穿戴系统将脑磁图移动到现实世界的应用

使用脑磁图等技术对人脑功能进行成像通常需要受试者执行任务，同时他们的头部仍保持在限制性扫描仪内。这种人工环境使许多人无法使用该技术，并限制了可以解决的实验问题。例如，很难将神经影像学应用于研究婴儿和儿童认知发展的神经基质，或研究需要不受约束的头部运动（如空间导航）的成人过程。在这里，我们描述了一种可以像头盔一样佩戴的脑磁图系统，允许在扫描过程中自由自然地移动。由于不依赖超导技术的量子传感器的集成，这是可能的，带有用于消除背景磁场的系统。我们以毫秒分辨率演示人体电生理测量，同时受试者进行自然运动，包括点头、伸展、喝酒和打球。我们的结果与当前最先进的结果相比很好，即使受试者进行大幅度的头部运动也是如此。该系统为扫描任何受试者或患者群体开辟了新的可能性，具有无数的应用，例如神经发育连接组的表征、在虚拟环境中自然移动的受试者成像以及研究运动障碍的病理生理学。我们的结果与当前最先进的结果相比很好，即使受试者进行大幅度的头部运动也是如此。该系统为扫描任何受试者或患者群体开辟了新的可能性，具有无数的应用，例如神经发育连接组的表征、在虚拟环境中自然移动的受试者成像以及研究运动障碍的病理生理学。我们的结果与当前最先进的结果相比很好，即使受试者进行大幅度的头部运动也是如此。该系统为扫描任何受试者或患者群体开辟了新的可能性，具有无数的应用，例如神经发育连接组的表征、在虚拟环境中自然移动的受试者成像以及研究运动障碍的病理生理学。

更新日期：2018-03-01

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