Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-induced fear behaviour, but it is unclear how they encode these distinct processes. Here, by recording calcium transients in vivo from individual neurons in mice, we show that most CGRPPBN neurons are activated by noxious cutaneous (shock, heat, itch) and visceral stimuli (lipopolysaccharide). The same neurons are inhibited during feeding, but become activated during satiation, consistent with evidence that CGRPPBN neurons prevent overeating. CGRPPBN neurons are also activated during consumption of novel foods or by an auditory cue that has previously been paired with electrical footshocks. Correspondingly, silencing of CGRPPBN neurons attenuates the expression of food neophobia and conditioned fear responses. Therefore, in addition to transducing primary sensory danger signals, CGRPPBN neurons promote affective-behavioural states that limit harm in response to potential threats.

中文翻译：

---

臂旁 CGRP 神经元对危险的编码

动物必须对各种威胁做出反应才能生存。在臂旁核中表达降钙素基因相关肽的神经元（CGRPPBN 神经元）传递有助于饱腹感和疼痛引起的恐惧行为的感觉信号，但尚不清楚它们如何编码这些不同的过程。在这里，通过记录小鼠个体神经元的体内钙瞬变，我们表明大多数 CGRPPBN 神经元被有害皮肤（休克、热、痒）和内脏刺激（脂多糖）激活。相同的神经元在进食期间受到抑制，但在饱食期间被激活，这与 CGRPPBN 神经元防止暴饮暴食的证据一致。CGRPPBN 神经元也在食用新食物期间或通过先前与电足震配对的听觉提示被激活。相应地，CGRPPBN 神经元的沉默减弱了食物恐惧症和条件性恐惧反应的表达。因此，除了转导主要的感官危险信号外，CGRPBN 神经元还促进情感行为状态，以限制对潜在威胁的伤害。