Tributyltin, an organotin compound, was used worldwide as an antifouling agent in aquatic environments and there has been much concern about the toxicological and ecotoxicological properties of organotin compounds. Even though it has been prohibited worldwide, tributyltin is still detected at low concentrations in aquatic environments. Here we investigated the effects of tributyltin on the early life-stage, reproduction, and gonadal sex differentiation in Japanese medaka (Oryzias latipes). In adults, exposure to tributyltin at 3.82 μg/L suppressed fecundity and fertility and increased mortality. At 10.48 μg/L all medaka died by the sixth day of exposure. Exposure to tributyltin during early life-stages induced no significant differences in mortality or embryonic development, but growth was suppressed in groups exposed to 0.13 and 0.68 μg/L. Furthermore, there was no abnormal gonadal development in Japanese medaka exposed to tributyltin. These results provide evidence of the negative effects of tributyltin on reproduction in a teleost fish. Tributyltin did not affect gonadal sex differentiation in Japanese medaka, but fecundity and fertility were suppressed, although it is not clear whether this suppression resulted from the endocrine-disrupting action of tributyltin or its toxicity.

三丁基锡是一种有机锡化合物，已在世界范围内用作水生环境中的防污剂，人们对有机锡化合物的毒理学和生态毒理学特性一直感到担忧。尽管全世界都禁止使用三丁基锡，但在水生环境中仍以低浓度检测到三丁基锡。在这里，我们调查了三丁基锡对日本（Oryzias latipes）的早期生命阶段，生殖和性腺性别分化的影响。）。在成年人中，以3.82μg/ L的剂量接触三丁基锡会抑制生育力和繁殖力，并增加死亡率。在暴露的第六天，所有高草以10.48μg/ L的速度死亡。在生命的早期阶段，暴露于三丁基锡中不会导致死亡率或胚胎发育的显着差异，但在0.13和0.68μg/ L的暴露组中，其生长受到了抑制。此外，暴露于三丁基锡的日本中没有发生异常的性腺发育。这些结果提供了三丁基锡对硬骨鱼繁殖的负面影响的证据。三丁基锡不影响日本花aka的性腺性别分化，但生殖力和生育能力受到抑制，尽管尚不清楚这种抑制作用是由三丁基锡的内分泌干扰作用还是其毒性所致。