Abstract We report the rapid microwave-assisted hydrothermal synthesis of mesoporous hydroxyapatite (HAp) nanocrystals with controlled size, morphology, and surface area using various organic modifiers as regulators. The products were analyzed for their crystalline nature, phase purity, morphology, particle size and pore size distribution. Results indicated that ascorbic acid, cetyltrimethyl ammonium bromide (CTAB) and polyvinylpyrrolidone (PVP) play an important role to obtain needle like, rod like and fiber like mesoporous HAp nanocrystals with different specific surface area by controlling growth habit of HAp along c -axis. In addition, the prepared samples were B-type carbonated HAp similar to bone minerals. Therefore, the present approach can be a promising way to obtain precursor for making tissue engineering scaffolds, drug/protein delivery carriers and bone fillers with tunable characteristics.

中文翻译：

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微波辅助水热法制备介孔羟基磷灰石纳米晶的尺寸和形态控制合成

摘要 我们报告了使用各种有机改性剂作为调节剂快速微波辅助水热合成具有可控尺寸、形态和表面积的介孔羟基磷灰石 (HAp) 纳米晶体。分析产物的结晶性质、相纯度、形态、粒度和孔径分布。结果表明，抗坏血酸、十六烷基三甲基溴化铵 (CTAB) 和聚乙烯吡咯烷酮 (PVP) 通过控制 HAp 沿 c 轴的生长习性，在获得具有不同比表面积的针状、棒状和纤维状介孔 HAp 纳米晶体方面发挥重要作用。此外，制备的样品是类似于骨矿物质的B型碳酸HAp。因此，本方法可以成为获得制备组织工程支架的前体的有前途的方法，