A novel synbiotic multiparticulate microparticle was produced in the current study to expand the synbiotic industrial applications. Initially, the inulin was fabricated into PLGA nanoparticles. After the inulin entrapment efficiency was boosted to reach 92.9 ± 8.4% by adjusting the formulation parameters, the developed particles were characterized by different techniques such as particle size analyzer, TEM, and TLC. The obtained data showed that the particle size was 115.8 ± 82.7 nm, the particles had smooth surface and round shape, and the fabrication procedure did not affect the integrity of the inulin. Later, the inulin loaded nanoparticles together with selected Bifidobacterium species were double coated with gum arabic and alginate. The maximum survivability of the encapsulated Bifidobacterium in the simulated gastric solution reached 88.29% of the initial population, which was significantly higher than the survivability of the free bacteria. Finally, the inulin release from the multiparticulate microparticles was studied and found to be sustained over three days.

在当前的研究中产生了新型的合生多颗粒微粒，以扩展合生工业应用。最初，菊粉被制成PLGA纳米颗粒。通过调整配方参数将菊粉的截留效率提高到92.9±8.4％之后，可通过不同的技术（例如粒度分析仪，TEM和TLC）对显影的颗粒进行表征。所得数据表明，粒径为115.8±82.7nm，颗粒具有光滑的表面和圆形，并且制备过程不影响菊粉的完整性。随后，将负载菊粉的纳米颗粒与选定的双歧杆菌物种一起用阿拉伯胶和藻酸盐进行双包衣。包埋的双歧杆菌在模拟胃液中的最大存活率达到88。初始种群的29％，显着高于游离细菌的生存能力。最后，研究了菊粉从多颗粒微粒中的释放，并持续了三天。