Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice,RSC Medicinal Chemistry

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Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1039/c7md00653e
Jing Meng ₁ , Xiaoqian Hu _{1,

2} , Tiantian Zhang ₁ , Ping Dong ₁ , Zhaojie Li ₁ , Changhu Xue _{1,

3} , Yaoguang Chang ₁ , Yuming Wang _{1,

3}

Affiliation

Obesity and its comorbidities are considered to be a severe public health problem. Many natural compounds found in food have been proved to ameliorate the metabolic abnormalities induced by obesity. The purpose of this study was to compare the effects of saponin from sea cucumber (SSC) and ginsenoside (SG) on improving the lipid metabolism in C57BL/6 mice fed with a high fat diet. The mice were randomly divided into six groups including a low fat diet group (LF), a high fat diet group (HF), and four dietary intervention groups. The administration of SSC for 8 weeks exhibited a more significant reduction in HF induced fat mass, weight gain, lipid levels in the liver and serum, and serum glucose and insulin levels than SG. Further research indicated that SSC ameliorated high fat diet-induced obesity in C57BL/6 mice mainly through inhibiting lipid synthesis and accelerating lipid β-oxidation and glycolysis in the liver. These results suggested that saponin from sea cucumber might be applied as a food supplement and/or functional ingredient to relieve metabolic disorders induced by obesity.

中文翻译：

海参皂苷对改善 C57BL/6 小鼠高脂饮食引起的肥胖的作用比人参皂苷更显着

肥胖及其合并症被认为是一个严重的公共卫生问题。食物中发现的许多天然化合物已被证明可以改善肥胖引起的代谢异常。本研究的目的是比较海参皂苷 (SSC) 和人参皂苷 (SG) 对改善高脂饮食喂养的 C57BL/6 小鼠脂质代谢的作用。将小鼠随机分为六组，包括低脂饮食组（LF）、高脂饮食组（HF）和四个饮食干预组。与SG相比，连续8周的SSC给药在HF诱导的脂肪量、体重增加、肝脏和血清中的脂质水平以及血清葡萄糖和胰岛素水平方面表现出更显着的降低。进一步的研究表明，SSC主要通过抑制肝脏中的脂质合成和加速脂质β-氧化和糖酵解来改善C57BL/6小鼠高脂饮食引起的肥胖。这些结果表明，海参皂苷可用作食品补充剂和/或功能成分，以缓解肥胖引起的代谢紊乱。

更新日期：2018-03-20

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