By employing easily accessible 2-alkynylanilines and the well-established fluoroform-derived CuCF₃ reagent, a novel class of 3-(trifluoromethyl)indoles can be synthesized in good yields with no ambiguity of the CF₃ position. The method utilizes a domino cyclization/trifluoromethylation strategy to construct the indole cores with the concomitant installation of the CF₃ group. The ultimate source of CF₃ is the low-cost industrial by-product fluoroform (CF₃H).

中文翻译：

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使用氟仿衍生的CuCF ₃进行2-炔基苯胺的多米诺环化/三氟甲基化：3-（三氟甲基）吲哚的合成†

通过使用容易获得的2-炔基苯胺和完善的源自氟仿的CuCF ₃试剂，可以以高收率合成新型的3-（三氟甲基）吲哚类，而不会混淆CF _3的位置。该方法利用多米诺环化/三氟甲基化策略来构建吲哚核，并同时安装CF ₃基团。CF ₃的最终来源是低成本的工业副产品氟仿（CF ₃ H）。