The chemistry of PET imaging with zirconium-89,Chemical Society Reviews

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The chemistry of PET imaging with zirconium-89
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1039/c7cs00014f
Jonathan R. Dilworth _{1,

2,

3,

4} , Sofia I. Pascu _{4,

5,

6,

7}

Affiliation

This Tutorial Review aims to provide an overview of the use of zirconium-89 complexes in biomedical imaging. Over the past decade there have been many new papers in this field, ranging from chemistry through to preclinical and clinical applications. Here we attempt to summarise the main developments that have occurred in this period. The primary focus is on coordination chemistry but other aspects such as isotope production, isotope properties, handling and radiochemical techniques and characterisation of cold and labelled complexes are included. Selected results from animal and human clinical studies are presented in the context of the stabilities and properties of the labelled bioconjugates.

中文翻译：

锆89的PET成像化学

本教程综述旨在概述在医疗医学成像中使用锆89配合物的情况。在过去的十年中，该领域出现了许多新论文，从化学到临床前和临床应用不等。在这里，我们试图总结这一时期发生的主要事态发展。主要重点是配位化学，但包括同位素生产，同位素性质，处理和放射化学技术以及冷和标记配合物的表征等其他方面。在标记的生物结合物的稳定性和特性的背景下，提供了来自动物和人类临床研究的部分结果。

更新日期：2018-03-20

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