AbstractA method is described for the rapid fluorometric determination of dopamine (DA) by using molybdenum disulfide quantum dots (MoS2 QDs) that were fabricated via an ammonium hydroxide etching method. The probe has a fluorescence (with excitation/emission peaks at 267/380 nm) that is quenched by DA with high selectivity over various interferences. This is attributed to a reaction that occurs between DA and the molybdate ions in pH 9 solutions of MoS2 QDs. The formation of organic molybdate complexes and of dopamine-quinone results in strong quenching of the fluorescence of the QDs which is due to both electron transfer and an inner filter effect. Under the optimum conditions, the assay works in the 0.1–100 μM DA concentration range, with two linear ranges and a 10 nM detection limit. The method was applied to the determination of DA in spiked artificial urine samples, where it gave recoveries ranging from 97.6 to 102.2%, demonstrating that the method a promising tool for rapid and selective detection of DA. Graphical abstractMoS2 QDs are facilely synthesized via the etching effect of ammonium hydroxide for highly selective fluorometric detection of dopamine.

中文翻译：

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使用二硫化钼量子点荧光测定多巴胺

摘要描述了一种使用通过氢氧化铵蚀刻方法制造的二硫化钼量子点 (MoS2 QD) 快速荧光测定多巴胺 (DA) 的方法。探针具有荧光（在 267/380 nm 处具有激发/发射峰），该荧光被 DA 淬灭，对各种干扰具有高选择性。这归因于 DA 和 MoS2 QD 的 pH 9 溶液中的钼酸盐离子之间发生的反应。有机钼酸盐配合物和多巴胺-醌的形成导致量子点荧光的强烈猝灭，这是由于电子转移和内部过滤效应。在最佳条件下，该检测在 0.1–100 μM DA 浓度范围内工作，具有两个线性范围和 10 nM 检测限。该方法用于测定加标人工尿液样品中的 DA，回收率范围为 97.6% 至 102.2%，表明该方法是快速和选择性检测 DA 的有前途的工具。图形抽象 MoS2 QDs 通过氢氧化铵的蚀刻作用轻松合成，用于多巴胺的高选择性荧光检测。