The present work evaluated the feasibility of different pluronics (F127, F87 and P85) utilized as modifiers to improve the stability and bioaccessibility of curcumin liposomes (cur-Lps). Pluronics modified curcumin liposomes (cur-pluronic-Lps) were prepared by thin film evaporation combined with dynamic high pressure microfluidization. The particle size and polydispersity index of cur-pluronic-Lps was significantly lower than cur-Lps. Fourier transform infrared spectroscopy analysis revealed that curcumin was loaded in liposomes successfully and X-ray diffraction suggested that curcumin in the liposomes was in an amorphous state. In vitro release studies demonstrated that 73.4%, 63.9%, 66.7% and 58.9% curcumin released from cur-Lps, cur-F127-Lps, cur-F87-Lps and cur-P85-Lps, respectively. Compared with cur-Lps, cur-pluronic-Lps showed a slower release rate and lower cumulative release percentage for curcumin. Non-Fickian transport was the main release mechanism for cur-Lps, cur-F127-Lps and cur-F87-Lps, and typically the first-order model fitted cur-P85-Lps release. Stability studies (exposure to solutions of different pH and heat treatment) indicated that pluronics modification could enhance their pH stability and thermal stability. In vitro simulated gastrointestinal tract studies suggested that pluronics modification could significantly improve the absorption of cur-Lps. Bioaccessibility of curcumin liposomes increased in the following order: cur-Lps < cur-F87-Lps < cur-P85-Lps < cur-F127-Lps. These results may guide the potential application of pluronics modified liposomes as carriers of curcumin in nutraceutical and functional foods.

本工作评估了不同的普鲁尼克尼克化合物（F127，F87和P85）用作改性剂以改善姜黄素脂质体（cur-Lps）的稳定性和生物可及性的可行性。通过薄膜蒸发结合动态高压微流化制备了Pluronics修饰的姜黄素脂质体（cur-pluronic-Lps）。cur-pluronic-Lps的粒径和多分散指数明显低于cur-Lps。傅里叶变换红外光谱分析表明姜黄素已成功地负载在脂质体中，X射线衍射表明脂质体中的姜黄素处于无定形状态。体外释放研究表明，姜黄素分别从cur-Lps，cur-F127-Lps，cur-F87-Lps和cur-P85-Lps释放73.4％，63.9％，66.7％和58.9％。与cur-Lps相比，cur-pluronic-Lps的姜黄素释放速度较慢，累积释放百分比较低。非菲克运子是cur-Lps，cur-F127-Lps和cur-F87-Lps的主要释放机制，通常是一阶模型拟合的cur-P85-Lps释放。稳定性研究（暴露于不同pH值和热处理的溶液中）表明，普朗尼克斯修饰可以增强其pH稳定性和热稳定性。体外模拟胃肠道研究表明，对ur子进行修饰可以显着改善cur-Lps的吸收。姜黄素脂质体的生物可及性按以下顺序增加：cur-Lps <cur-F87-Lps <cur-P85-Lps <cur-F127-Lps。这些结果可能指导普鲁尼克斯修饰脂质体作为姜黄素载体在营养保健食品和功能性食品中的潜在应用。