While wound therapy remains a clinical challenge in current medical practice, much effort has focused on developing biological therapeutic approaches. This paper presents a comprehensive review of delivery systems for current biologicals for the treatment of chronic wounds and severe burns. The biologicals discussed here include proteins such as growth factors and gene modifying molecules, which may be delivered to wounds free, encapsulated, or released from living systems (cells, skin grafts or skin equivalents) or biomaterials. Advances in biomaterial science and technologies have enabled the synthesis of delivery systems such as scaffolds, hydrogels and nanoparticles, designed to not only allow spatially and temporally controlled release of biologicals, but to also emulate the natural extracellular matrix microenvironment. These technologies represent an attractive field for regenerative wound therapy, by offering more personalised and effective treatments.

尽管伤口治疗在当前医学实践中仍然是临床挑战，但是许多努力集中在开发生物治疗方法上。本文对用于治疗慢性伤口和严重烧伤的当前生物制剂的输送系统进行了全面的综述。本文讨论的生物制剂包括诸如生长因子和基因修饰分子之类的蛋白质，它们可以从生物系统（细胞，皮肤移植物或皮肤等同物）或生物材料中释放，包裹或释放到伤口上。生物材料科学和技术的进步使得能够合成诸如支架，水凝胶和纳米颗粒之类的递送系统，这些递送系统不仅能够在空间和时间上控制生物的释放，而且能够模仿自然的细胞外基质微环境。