The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals. Ten untreated, sound English bulldogs were used as a reference group. Clinical outcomes were evaluated using a linear mixed effects model. Mean values of PVF, VI, ST, and AROM were improved within the first 3 months post-treatment in the CCLR group, with mean measured changes increasing to maximum 4.56% body weight gain, 1.5% body weight/second, 0.07 seconds, and 6.18 degrees, respectively. The effects declined progressively after the treatment interval, ending at nearly initial levels after 6 months. This study demonstrates that dogs with CCLR treated with intra-articular PRP had improved PVF, VI, ST, and AROM over time; the duration of effect was waning by the end of the post-treatment period.

这项研究的目的是客观评估衍生于颅交叉韧带断裂（CCLR）的窒息性退化性关节病的英国斗牛犬中富含血小板的血浆（PRP）衍生物的作用。我们使用了一个测力平台和附加的电子测角仪来测量来自12个la脚的，客户自备的英国斗牛犬的峰值垂直力（PVF），垂直脉冲（VI），站立时间（ST）和运动角度范围（AROM）窒息关节异常。以30天为间隔，通过4次关节腔内注射PRP治疗12位患病受试者。十只未经治疗的，健全的英国斗牛犬被用作参考组。使用线性混合效应模型评估临床结局。CCLR组在治疗后的前3个月内，PVF，VI，ST和AROM的平均值有所改善，平均测得的变化分别增加到最大4.56％体重增加，1.5％体重/秒，0.07秒和6.18度。在治疗间隔后效果逐渐下降，在6个月后几乎接近初始水平。这项研究表明，经关节内PRP治疗的CCLR狗随着时间的推移具有改善的PVF，VI，ST和AROM。在治疗期结束时，作用的持续时间逐渐减少。