Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis†,Chemical Communications

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Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1039/c7cc09809j
V. V. Begoyan _{1,

2,

3,

4,

5} , Ł. J. Weseliński _{1,

2,

3,

4,

5} , S. Xia _{1,

2,

3,

4,

5} , J. Fedie _{1,

2,

3,

4,

5} , S. Kannan _{2,

3,

4,

5,

6} , A. Ferrier _{1,

2,

3,

4,

5} , S. Rao _{2,

3,

4,

5,

6} , M. Tanasova _{1,

2,

3,

4,

5}

Affiliation

The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.

中文翻译：

用于果糖转运分析的多色GLUT5渗透荧光探针†

对于生物化学和生物医学应用，碳水化合物转运蛋白对其底物的特异性对监测细胞中糖摄取的分子探针的开发提出了重大挑战。本文中，我们报告了一套新的基于香豆素的荧光糖结合物，可用于分析果糖的摄取，因为它们可以自由通过果糖特异性转运蛋白GLUT5。报告的探针涵盖了广泛的荧光光谱，为评估活细胞中果糖的运输能力提供了必不可少的工具。

更新日期：2018-03-19

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