Biotin-functionalized targeted polydiacetylene micelles†,Chemical Communications

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Biotin-functionalized targeted polydiacetylene micelles†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1039/c8cc00553b
Anaëlle Doerflinger _{1,

2,

3,

4,

5} , Nam Nguyen Quang _{2,

3,

5,

6,

7} , Edmond Gravel _{1,

2,

3,

4,

5} , Guillaume Pinna _{2,

8,

9,

10,

11} , Marie Vandamme _{2,

8,

9,

10,

11} , Frédéric Ducongé _{2,

3,

5,

6,

7} , Eric Doris _{1,

2,

3,

4,

5}

Affiliation

Polydiacetylene micelles were functionalized with controlled amounts of biotin using bioorthogonal click chemistry. The biotinylated micelles were evaluated in the selective targeting of the MCF-7 cancerous cell line and were shown to be readily internalized. The efficiency of the cellular uptake was correlated to the density of grafted biotin.

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