Isochamigrene, a side product of the trichodiene synthase, which is a key enzyme from the biosynthesis of the trichothecene mycotoxins from Fusarium spp., was enantioselectively synthesised and compared to the natural product from Fusarium sporotrichioides. As a result, its absolute configuration was assigned to (S)-isochamigrene. Implications for the recently extensively discussed cyclisation mechanism towards trichodiene and its side products are discussed.

中文翻译：

---

异沙米grene的绝对构型：对滴虫二烯合酶环化机制的新见解†

对映体选择性合成的曲霉二烯合酶的副产物异丁二烯是从镰孢属（Fusarium spp。）的单端孢霉菌真菌毒素生物合成的关键酶，并与孢子镰孢（Fusarium sporotrichioides）的天然产物进行了比较。结果，其绝对构型被分配给（S）-异香米烯。讨论了对于最近被广泛讨论的对三氯二烯及其副产物的环化机理的影响。