Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair.

由于水凝胶的生物相容性和与天然细胞外基质的结构相似性，水凝胶已在再生应用中使用了数十年。最初，这些材料在患者体外形成，并使用侵入性外科手术技术植入。但是，合成化学和材料科学的进步为研究人员提供了一个技术库，通过标准针头递送后，水凝胶的形成可以就地发生。这提供了一种途径，以微创方式传递治疗有效载荷，填充复杂的组织缺陷并诱导机体受损部位的再生。在这篇综述中，我们在药物输送和组织再生以修复皮肤伤口的背景下重点介绍了这些可注射的治疗性水凝胶生物材料。